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Tetrahedron

Oxazole light triggered protecting groups: synthesis and photolysis of fused heteroaromatic conjugates

AMS Soares, SPG Costa, MST Gonçalves

文献索引:Soares, Ana M.S.; Costa, Susana P.G.; Gonalves, M. Sameiro T. Tetrahedron, 2010 , vol. 66, # 41 p. 8189 - 8195

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被引用次数: 31

摘要

Fused oxazole derivatives were synthesized and evaluated as new light triggered protecting groups by using amino acids as model bifunctional molecules. The photosensitivity of ester conjugates was tested under irradiation at 254, 300, and 350 nm. Oxazole conjugates were readily photolyzed with complete release of the amino acid, the best results obtained for naphtho [2, 3-d] oxazole at 254 and 300 nm, being the first reported application of this type ...