2, 3-Dihydrobenzofuran-2-ones: a new class of highly potent antiinflammatory agents

…, HU Gubler, B Dewald, M Baggiolini

文献索引：Closse, Annemarie; Haefliger, Walter; Hauser, Daniel; Gubler, Hans Ulrich; Dewald, Beatrice; Baggiolini, Marco Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1465 - 1471

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被引用次数: 28

摘要

Method B is based on the reaction of the phenol 33 with oxalylchloride and subsequent hydrolysis to the keto acid 34. This reaction appears to be highly regioselective, since in this and other cases no isomeric produds were detected. Reduction of the keto function was accomplished by conversion of 34 into the dithiolane derivative 35 and subsequent desulfurization with hey nickel. Keto acid 34 was also used as the starting material for the ...