Development of an enabling route to PF-00610355: a novel inhaled β2-adrenoreceptor agonist

PD de Koning, IR Gladwell, IB Moses…

文献索引：Organic Process Research and Development, , vol. 15, # 6 p. 1247 - 1255

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被引用次数: 5

摘要

... However, the published procedure for the asymmetric reduction of 16(14) provided only ∼97 ... Since 8 has limited solubility in most common organic solvents, we recognized that separating 8 ... Subsequent work to develop a more suitable process for long-term manufacture of 8 ...