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Total Synthesis of the Biphenomycins; V. 1 Synthesis of Biphenomycin A

U Schmidt, V Leitenberger, H Griesser, J Schmidt…

文献索引：Schmidt; Leitenberger; Griesser; Meyer Synthesis, 1992 , # 12 p. 1248 - 1254

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被引用次数: 45

摘要

Synthesis of Hydroxydiisotyrosine by the Enolate Method The reaction sequence is illustrated in Scheme 2. The aryl bromide 16 represents a completely protected 2-hydroxy-5- bromophenylserine and can be prepared via 15 by the Evans method. 23 The palladium (0)- catalyzed coupling of 16 with the boronic acid 17 containing an unprotected aldehyde function gives rise to the biphenyl derivative 18. The stated reaction conditions must be ...

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