Synthetic Prodiginine Obatoclax (GX15??070) and Related Analogues: Anion Binding, Transmembrane Transport, and Cytotoxicity Properties

…, T Torroba, R Pérez??Tomás, R Quesada

文献索引：Diaz De Grenu, Borja; Hernandez, Paulina Iglesias; Espona, Margarita; Quinonero, David; Light, Mark E.; Torroba, Tomas; Perez-Tomas, Ricardo; Quesada, Roberto Chemistry - A European Journal, 2011 , vol. 17, # 50 p. 14074 - 14083

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被引用次数: 43

摘要

Abstract Synthetic prodiginine obatoclax shows promise as a potential anticancer drug. This compound promotes apoptosis of cancer cells, although the mechanism of action is unclear. To date, only the inhibition of BCL-2 proteins has been proposed as a mechanism of action. To gain insight into other possible modes of action, we have studied the anion-binding properties of obatoclax and related analogues in solution, in the solid state, and by means ...