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Tandem Synthesis of 3-Halo-5-Substituted Isoxazoles from 1-Copper (I) Alkynes and Dihaloformaldoximes

W Chen, B Wang, N Liu, D Huang, X Wang, Y Hu

文献索引:McIntosh, Melissa L.; Naffziger, Michael R.; Ashburn, Bradley O.; Carter, Rich G.; Zakharov, Lev N. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 46 p. 9204 - 9213,10

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被引用次数: 9

摘要

... premade 7a was employed as a substrate because it could not be generated from 8a and CuSO 4 ·5H 2 O/NaAsc (sodium ascorbate)(9f) in an organic solvent ... of 4 as a substrate achieved higher efficiency (shorter time and higher yield) than that of 3. On a 1.5-g scale, 2k ...