Salicylate–urea-based soluble epoxide hydrolase inhibitors with high metabolic and chemical stabilities

…, HJ Tsai, K Nishi, BD Hammock, C Morisseau

文献索引：Kasagami, Takeo; Kim, In-Hae; Tsai, Hsing-Ju; Nishi, Kosuke; Hammock, Bruce D.; Morisseau, Christophe Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1784 - 1789

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被引用次数: 27

摘要

We investigated N-adamantyl-N′-phenyl urea derivatives as simple sEH inhibitors. Salicylate ester derivatives have high inhibitory activities against human sEH, while the free benzoic acids are less active. The methyl salicylate derivative is a potent sEH inhibitor, which also has high metabolic and chemical stabilities; suggesting that such inhibitors are potential lead molecule for bioactive compounds acting in vivo.