Synthesis and Biological Evaluation of Purine 2′??Fluoro??2′??deoxyriboside ProTides as Anti??influenza Virus Agents

S Meneghesso, E Vanderlinden, A Brancale…

文献索引：Meneghesso, Silvia; Vanderlinden, Evelien; Brancale, Andrea; Balzarini, Jan; Naesens, Lieve; Mcguigan, Christopher ChemMedChem, 2013 , vol. 8, # 3 p. 415 - 425

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被引用次数: 5

摘要

Abstract 2′-Fluoro-2′-deoxyguanosine has been reported to have potent anti-influenza virus activity in vitro and in vivo. Herein we describe the synthesis and biological evaluation of 6-modified 2′-fluoro-2′-deoxyguanosine analogues and their corresponding phosphoramidate ProTides as potential anti-influenza virus agents. Whereas the parent nucleosides were devoid of antiviral activity in two different cellular assays, the 5′-O- ...