Journal of fluorine chemistry

Preparation of optically active 2-(trifluoromethyl) alkan-1-ols by catalytic asymmetric hydrogenation

K Iseki, Y Kuroki, T Nagai, Y Kobayashi

文献索引：Iseki, Katsuhiko; Kuroki, Yoshichika; Nagai, Takabumi; Kobayashi, Yoshiro Journal of Fluorine Chemistry, 1994 , vol. 69, # 1 p. 5 - 6

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被引用次数: 27

摘要

Abstract The hydrogenation of (E)-2-(trifluoromethyl) alk-2-en-1-ols catalyzed by Ru-BINAP and Rh-BINAP has been carried out with good enantiomeric excess (71%–83% ee). Ru- BINAP-catalyzed hydrogenation converted 2-trifluoromethyl-acrylic acid to the corresponding saturated acid, the ester-ification and reduction of which gave optically active 2-(trifluoromethyl) propan-1-ol in 80% ee.