Il Farmaco

Synthesis, crystal structure and antiproliferative evaluation of some new substituted benzothiazoles and styrylbenzothiazoles

…, V Tralić-Kulenović, K Pavelić, G Karminski-Zamola

文献索引：Caleta; Grdisa; Mrvos-Sermek; Cetina; Tralic-Kulenovic; Pavelic; Karminski-Zamola Farmaco, 2004 , vol. 59, # 4 p. 297 - 305

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被引用次数: 57

摘要

The multistep synthesis of a series of new substituted-benzothiazoles as hydrochloride or quaternary salts is described. 6-Amidino substituted 2-aminobenzothiazoles (5, 6), N-methyl- 2-(4-cyanostyryl) benzothiazolium iodide (8), cyano-substituted-2-styrylbenzothiazoles (9- 11) and amidino and bis-amidino-substituted 2-styrylbenzothiazoles (12-17) were prepared. The crystal structure of amidino derivative (6) was determined by single crystal X-ray ...