Novel 9-Alkyl-and 9-Alkylidene-Substituted 1α, 25-Dihydroxyvitamin D3 Analogues: Synthesis and Biological Examinations

…, LA Plum, HF DeLuca, A Mourino…

文献索引：Gogoi, Pranjal; Sigueeiro, Rita; Eduardo, Silvina; Mourino, Antonio Chemistry - A European Journal, 2010 , vol. 16, # 5 p. 1432 - 1435

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被引用次数: 2

摘要

Continuing the structure–activity relationship studies in the vitamin D area, we designed and synthesized novel C-9 substituted calcitriol analogues, possessing different nonpolar groups at this position. 9α-Methyl-1α, 25-(OH) 2D3, both epimers of 9-methylene-10, 19-dihydro-1α,