4-[5-Methyl-3-phenylisoxazol-4-yl]-benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2

…, MJ Graneto, CM Koboldt, JL Masferrer…

文献索引：Talley, John J.; Brown, David L.; Carter, Jeffery S.; Graneto, Matthew J.; Koboldt, Carol M.; Masferrer, Jaime L.; Perkins, William E.; Rogers, Roland S.; Shaffer, Alexander F.; Zhang, Yan Y.; Zweifel, Ben S.; Seibert, Karen Journal of Medicinal Chemistry, 2000 , vol. 43, # 5 p. 775 - 777

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被引用次数: 599

摘要

Introduction. Nonsteroidal antiinflammatory drugs (NSAIDs) are among the most widely used prescription and over the counter medications, used primarily for the treatment of pain and inflammation, particularly arthritis. In the 1970s, it was demonstrated that aspirin and other NSAIDs block the formation of prostaglandins (PGs) produced from arachidonic acid by the enzyme cyclooxygenase (COX), sometimes called prostaglandin synthase. 1 PGs are ...