Tetrahedron letters

A novel modification of the Ritter reaction using trimethylsilyl cyanide

HG Chen, OP Goel, S Kesten, J Knobelsdorf

文献索引：Chen; Goel; Kesten; Knobelsdorf Tetrahedron Letters, 1996 , vol. 37, # 45 p. 8129 - 8132

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被引用次数: 28

摘要

A new modification of the Ritter reaction using trimethylsilyl cyanide (Me3SiCN) is described, which converts alcohols to their corresponding formamides in high yields using a convenient procedure. The reaction conditions and mechanism are discussed. In some cases, new formamides are synthesized which cannot be prepared by the classical Ritter reaction.