N 6-[(hetero) aryl/(cyclo) alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with …

…, S Baraldi, R Romagnoli, AR Moorman, S Gessi…

文献索引：Baraldi, Pier Giovanni; Preti, Delia; Tabrizi, Mojgan Aghazadeh; Fruttarolo, Francesca; Saponaro, Giulia; Baraldi, Stefania; Romagnoli, Romeo; Moorman, Allan R.; Gessi, Stefania; Varani, Katia; Borea, Pier Andrea Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 7 p. 2514 - 2527

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被引用次数: 52

摘要

A new series of N6-[(hetero) aryl/(cyclo) alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5′-N- ethylcarboxamido-adenosines (24–43) has been synthesised and tested in binding assays at hA1, hA2A and hA3 adenosine receptors, and in a functional assay at the hA2B subtype. The examined compounds displayed high potency in activating A2B receptors with good selectivity versus A2A subtypes. The introduction of an unsubstituted 4-[(phenylcarbamoyl ...