Tetrahedron Letters

Design and synthesis of a multi-detachable benzhydrylamine-resin for solid phase peptide synthesis

JP Tam, RD DiMarchi, RB Merrifield

文献索引：Tam, James P.; DiMarchi, Richard D.; Merrifield, R. B. Tetrahedron Letters, 1981 , vol. 22, # 30 p. 2851 - 2854

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被引用次数: 25

摘要

Abstract Peptides with C-terminal α-carboxamides were synthesized from a multi-detachable benzhydrylamine-resin containing a Boc-(4-acetoxy) benzhydryl-amine handle of unambiguous origin. The peptides bound to the new resin are stable to trifluoroacetic acid, but are cleavable by hydrogen fluoride, base and nucleophiles to give unprotected or protected peptide fragments.