Organic letters

Solid-phase synthesis of 3-alkylamino-1, 2, 4-triazoles

GM Makara, Y Ma, L Margarida

文献索引：Makara, Gergely M.; Ma, Yao; Margarida, Laura Organic Letters, 2002 , vol. 4, # 10 p. 1751 - 1754

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被引用次数: 33

摘要

A solid-phase synthesis of trisubstituted 3-alkylamino-1, 2, 4-triazoles has been developed. The synthesis utilizes immobilized N-acyl-1 H-benzotriazole-1-carboximidamides as key intermediates. Cyclization with hydrazines under mild conditions furnishes the title compounds with regioselectivity and high purity.