From ATP to AZD6140: the discovery of an orally active reversible P2Y 12 receptor antagonist for the prevention of thrombosis

B Springthorpe, A Bailey, P Barton…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 21 p. 6013 - 6018

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被引用次数: 161

摘要

... Please enable JavaScript to use all the features on this page. Bioorganic & Medicinal Chemistry Letters. ... Using ATP, the natural antagonist (pIC 50 = 3.5) of the P2Y 12 receptor, as a chemical starting point, we discovered 1 (AR-C69931MX, cangrelor, Fig. ...