Direct preparation of [N, C α]-diprotected L-α-aminoadipic acid from L-lysine

JE Baldwin, P Harrison, JA Murphy

文献索引：Baldwin, Jack E.; Harrison, Paul; Murphy, John A. Journal of the Chemical Society, Chemical Communications, 1982 , # 15 p. 818 - 819

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摘要

L- Lysine was converted into N-benzyloxycarbonyl-La-aminoadipic acid 1 -benzyl ester by a short route which avoids the intermediacy of La-aminoadipic acid. ... La-Aminoadipic acid is of crucial importance in biosynthetic studies on penicillin since it is a component of the LLD-ACV tripeptide (l), which has been shown to be a precursor of penicillin1 and subsequently the cephalosporins.2 Consequently there has been a demand for preparative methods for (l), ...