Polyamine analogs with antitumor activity

ML Edwards, NJ Prakash, DM Stemerick…

文献索引：Edwards; Prakash; Stemerick; Sunkara; Bitonti; Davis; Dumont Journal of Medicinal Chemistry, 1990 , vol. 33, # 5 p. 1369 - 1375

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被引用次数: 67

摘要

A series of tetraamines derived from 1, 8-diaminooctane was prepared and tested as antitumor agents. The reaction of l&diaminooctane with acrylonitrile gave N,”-bis (cyanoethyl)-1, 8-diaminooctane, which was reduced to tetramine 20. Alkylation of the terminal nitrogen atoms of the tetra-Boc derivative of this compound by methyl or ethyl halide followed by removal of the Boc groups gave the bis (alky1) polyamines 26a and 26b, ...