Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones

…, RS Ferreira, JRB Fradico, PS Lage, MC Duarte…

文献索引：Braga, Saulo F.P.; Alves, Erika V.P.; Ferreira, Rafaela S.; Fradico, Jordana R.B.; Lage, Paula S.; Duarte, Mariana C.; Ribeiro, Tatiana G.; Junior, Policarpo A.S.; Romanha, Alvaro J.; Tonini, Maiko L.; Steindel, Mario; Coelho, Eduardo F.; De Oliveira, Renata B. European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 282 - 289

全文：HTML全文

被引用次数: 11

摘要

Abstract A series of bis-(arylmethylidene)-cycloalkanones was synthesized by cross-aldol condensation. The activity of the compounds was evaluated against amastigotes forms of Trypanosoma cruzi and promastigotes forms of Leishmania amazonensis. The cytotoxicity of the active compounds on uninfected fibroblasts or macrophages was established in vitro to evaluate the selectivity of their antiparasitic effects. Six compounds displayed trypanocidal ...