Hydrogen peroxide activated matrix metalloproteinase inhibitors: A prodrug approach

JL Major Jourden, SM Cohen

文献索引：Major Jourden, Jody L.; Cohen, Seth M. Angewandte Chemie - International Edition, 2010 , vol. 49, # 38 p. 6795 - 6797

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被引用次数: 68

摘要

Matrix metalloproteinases (MMPs) are a family of structurally related ZnII-dependent hydrolytic enzymes involved in the breakdown of the extracellular matrix.[1] MMPs are secreted as zymogens, and are activated by cleavage of the propeptide domain by proteases, other MMPs, or by reactive oxygen species (ROS). In particular, the activation of MMPs by ROS during ischemia-induced inflammatory response leads to the breakdown of ...