Synthesis and pharmacological evaluation of 2-(1-alkylpiperidin-4-yl)-n-[(1r)-1-(4-fluorophenyl)-2-methylpropyl] acetamide Derivatives as Novel Antihypertensive …
S Watanuki, K Matsuura, Y Tomura, M Okada…
文献索引：Watanuki, Susumu; Matsuura, Keisuke; Tomura, Yuichi; Okada, Minoru; Okazaki, Toshio; Ohta, Mitsuaki; Tsukamoto, Shin-Ichi Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 2 p. 223 - 234
We synthesized and evaluated the inhibitory activity of a series of 2-(1-alkylpiperidin-4-yl)-N- [(1R)-1-(4-fluorophenyl)-2-methylpropyl] acetamide derivatives against T-type Ca 2+ channels. Structure–activity relationship studies revealed that the position of the amide structure was important for the potent inhibitory activity toward T-type Ca 2+ channels. In addition, the introduction of an appropriate substituent on the pendant benzene ring ...
