Synthesis of 2-phenyl-, 3-phenyl-, cis-2, 3-diphenyl-, and trans-2, 3-diphenyl-1, 4-thiazanes and derivatives (N-methyl, N-alkoxycarbonyl, S-oxides, and S, S-dioxides)
…, JH Rodriguez, EM Olefirowicz, EL Eliel
文献索引：Ruano, J. L. Garcia; Martinez, M. C.; Rodriguez, J.H.; Olefirowicz, E. M.; Eliel, Ernest L. Journal of Organic Chemistry, 1992 , vol. 57, # 15 p. 4215 - 4224
The syntheses of the title 1, 4-thiazanes (thiamorpholines) by reduction of the 5-oxa-1, 4- thiazanes resulting from the lactamization of the appropriate acyclic phenyl derivatives of 5- amino-3-thiapentanoic acid are reported. The oxidation reactions at sulfur yielded the corresponding sulfoxides and sulfones. The stereochemistry of all these compounds was unequivocally established from their'H-NMR spectroscopic parameters.
