Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis

W Zeng, W Miao, G Kabalka, M Le Puil, J Biggerstaff…

文献索引：Zeng, Wenbin; Miao, Weimin; Kabalka, George; Puil, Michael Le; Biggerstaff, John; Townsend, David Tetrahedron Letters, 2008 , vol. 49, # 45 p. 6429 - 6432

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被引用次数: 5

摘要

To develop a small molecule-based biomarker for in vivo apoptosis imaging, a dansyled amino acid derivative (BNSBA) was designed and synthesized in good yield. The biological evaluation demonstrated that BNSBA selectively binds to apoptotic cancer cells and is localized within the cytoplasm of cells that bound annexin V on the plasma membrane.