A red-emitting naphthofluorescein-based fluorescent probe for selective detection of hydrogen peroxide in living cells

…, BC Dickinson, EW Miller, CJ Chang

文献索引：Albers, Aaron E.; Dickinson, Bryan C.; Miller, Evan W.; Chang, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 22 p. 5948 - 5950

全文：HTML全文

被引用次数: 60

摘要

We report the synthesis, properties, and cellular application of Naphtho-Peroxyfluor-1 (NPF1), a new fluorescent indicator for hydrogen peroxide based on a red-emitting naphthofluorescein platform. Owing to its boronate cages, NPF1 features high selectivity for hydrogen peroxide over a panel of biologically relevant reactive oxygen species (ROS), including superoxide and nitric oxide, as well as excitation and emission profiles in the far- ...