Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists

…, M Sugumaran, JS Saggu, P Balakumar, G Kaur…

文献索引：Bali, Alka; Bansal, Yogita; Sugumaran; Saggu, Jatinder Singh; Balakumar; Kaur, Gurpreet; Bansal, Gulshan; Sharma, Ajay; Singh, Manjeet Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 17 p. 3962 - 3965

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被引用次数: 74

摘要

5-Nitrobenzimidazole coupled through a methylene linker to biphenyl carboxylic acid has been synthesized and evaluated for angiotensin II antagonism activity. On the basis of their higher activity over standard compounds, a binding profile for benzimidazole-based compounds has been proposed. Alkyl group at 2-position has also been optimized with respect to 5-substituent. ... Angiotensin II (Ang II) receptor antagonists are widely accepted as novel ...