Efficient regioselective aldol condensation of methyl ketones promoted by organoaluminium compounds, and its application to muscone synthesis

J Tsuji, T Yamada, M Kaito, T Mandai

文献索引：Tsuji, Jiro; Yamada, Toshiro; Kaito, Mitsumasa; Mandai, Tadakatsu Bulletin of the Chemical Society of Japan, 1980 , vol. 53, # 5 p. 1417 - 1420

全文：HTML全文

被引用次数: 25

摘要

Dialkylaluminium aryloxide in combination with a tertiary amine was found to be a good reagent for regioselective aldol condensation of methyl ketones at the methyl side. Regioselective aldol condensation of 2-octanone was carried out using diisobutylaluminium phenoxide–pyridine. The intramolecular aldol condensation of 2, 15-hexadecanedione promoted by the same reagent gave a mixture of dehydromuscones in 65% yield. Its ...