Design, synthesis, and evaluation of proline based melanocortin receptor ligands

…, D Crossdoersen, BB Pinney, RJ Sheldon

文献索引：Tian, Xinrong; Field, Timothy; Mazur, Adam W.; Ebetino, Frank H.; Wos, John A.; Crossdoersen, Doreen; Pinney, Beth B.; Sheldon, Russell J. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 11 p. 2819 - 2823

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被引用次数: 14

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A series of proline based melanocortin ligands has been developed on the basis of initial piperazine leads by using a more conformationally rigid scaffold. A number of these novel ligands showed significant binding affinity for MC3 and MC4 receptors. ... A series of proline based ...