1, 2??Diastereoselective C–C Bond??Forming Reactions for the Synthesis of Chiral β??Branched α??Amino Acids

T Spangenberg, A Schoenfelder…

文献索引：Spangenberg, Thomas; Schoenfelder, Angele; Breit, Bernhard; Mann, Andre European Journal of Organic Chemistry, 2010 , # 31 p. 6005 - 6018

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被引用次数: 3

摘要

Abstract SN 2′ sequences have been employed for the synthesis of β-branched α-amino acids using 1, 2-diastereocontrol for forming C–C bonds. An oxazolidine fragment derived from Garner's aldehyde provides the handle for facial discrimination and acts as a masked amino acid functionality. This study encompasses directed and non-directed allylic substitution reactions. The stereocontrol of the oxazolidine appendage during terminal ...