Tetrahedron

Penicillin biosynthesis the immediate origin of the sulphur atom

JE Baldwin, RM Adlington, HH Ting, D Arigoni, P Graf…

文献索引：Baldwin; Adlington; Ting; et al. Tetrahedron, 1985 , vol. 41, # 16 p. 3339 - 3343

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被引用次数: 14

摘要

A mixture of tripeptide isotopomers δ-(L-α-aminoadipyl)-L-cystelnyl-D [2-2H]-valine and δ-(L- α-aminoadipyl)-L-(34S-cysteinyl)-D-valine were converted by the enzyme isopenicillin-N- synthetase into isopenicillin N. The distribution of the 2H and 34S in this product, determined by mass spectrometry, showed there was no transfer of the sulphur between the precursor molecules during conversion to penicillin.