Synthesis and anti-human immunodeficiency virus type 1 activities of new peptido-nucleoside analogues

M Camplo, V Niddam, P Barthelemy, P Faury…

文献索引：Camplo; Niddam; Barthelemy; Faury; Mourier; Simon; Charvet; Trabaud; Graciet; Chermann; Kraus European Journal of Medicinal Chemistry, 1995 , vol. 30, # 10 p. 789 - 800

全文：HTML全文

被引用次数: 19

摘要

In order to investigate whether antiproteasic peptides coupled to anti-reverse transcriptase nucleosides can act as inhibitors at the different stages of the HIV life cycle, various peptido- nucleosides were synthesized using methodologies involving (benzotriazol-1-yloxy)-tris (dimethylamino) phosphonium hexafluorophosphate (BOP) as a coupling reagent between the N4-cytosinyl moiety and the peptide carboxy terminus. The anti-HIV-1 activity in MT4 ...