Tetrahedron: Asymmetry

Asymmetric transfer hydrogenation in aqueous media catalyzed by resin-supported peptide having a polyleucine tether

K Akagawa, H Akabane, S Sakamoto, K Kudo

文献索引：Akagawa, Kengo; Akabane, Hajime; Sakamoto, Seiji; Kudo, Kazuaki Tetrahedron Asymmetry, 2009 , vol. 20, # 4 p. 461 - 466

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被引用次数: 29

摘要

A resin-supported N-terminal prolyl peptide having a β-turn motif and a polyleucine tether has been developed for the organocatalytic asymmetric transfer hydrogenation under aqueous conditions. Polyleucine accelerated the reaction in a highly enantioselective manner by providing a hydrophobic microenvironment around the prolyl residue. The investigation of catalyst structures indicates that the l-form of polyleucine is essential for ...