Tetrahedron

Investigation of amination in 4-chloro-2-phenylquinoline derivatives with amide solvents

…, CS Chang, YF Huang, HS Chen, SK Lin, FF Wong…

文献索引：Tsai, Jui-Ying; Chang, Chih-Shiang; Huang, Yi-Fan; Chen, Hua-Shin; Lin, Shao-Kai; Wong, Fung Fuh; Huang, Li-Jiau; Kuo, Sheng-Chu Tetrahedron, 2008 , vol. 64, # 51 p. 11751 - 11755

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被引用次数: 12

摘要

Novel 4-amino-2-phenylquinoline derivatives were synthesized by reacting various 4-chloro- 2-arylquinoline compounds having activated chloro group with the corresponding amide solvents at reflux for overnight. The activity of amination by the amide solvents depended on the competition between the steric and electronic effect of the N-substituents on the amino group. Their activities were shown as N, N-dimethylformamide> N, N-diethylformamide> N ...