Allenic amino acids. 1. Synthesis of. gamma.-allenic GABA by a novel aza-Cope rearrangement

AL Castelhano, A Krantz

文献索引：Castelhano,A.L.; Krantz,A. Journal of the American Chemical Society, 1984 , vol. 106, p. 1877

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被引用次数: 34

摘要

1 C= Rq= Hq, R2= CHs reactivity of relevant P, y-acetylenic amines and amino acid^.^,^ Despite the mechanistic rationale for" suicide inhibition", the corresponding allenic amino acids have not been de~ cribed.~,~ This is unfortunate as allenes are of special interest because they can be made chiral and thus offer possibilities for specific enzyme inhibition that are not available to acetylenes.'O We now wish to report the first example of the ...