Tetrahedron letters

Synthesis of deuterium labeled compounds by KCN-assisted hydrolysis of phosphonium salts

KY Lee, JE Na, MJ Lee, JN Kim

文献索引：Lee, Ka Young; Na, Jeong Eun; Lee, Mi Jung; Kim, Jae Nyoung Tetrahedron Letters, 2004 , vol. 45, # 31 p. 5977 - 5981

全文：HTML全文

被引用次数: 16

摘要

We developed a facile deuterium labeling method for benzylic or allylic halides or acetates systems. Conversion of the halides or acetates to the corresponding phosphonium salts and the following mild hydrolysis with KCN afforded the deuterium labeled compounds in good yields.