Chemo-enzymatic route for (R)-terbutaline hydrochloride based on microbial asymmetric reduction of a substituted α-chloroacetophenone derivative

S Taketomi, M Asano, T Higashi, M Shoji…

文献索引：Taketomi, Shohei; Asano, Masayoshi; Higashi, Toshinori; Shoji, Mitsuru; Sugai, Takeshi Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 84, p. 83 - 88

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被引用次数: 9

摘要

To synthesize (R)-terbutaline hydrochloride, a potent β2-adrenoceptor-stimulating agent, asymmetric reduction of a substituted α-chloroacetophenone derivative with cultured whole- cell biocatalyst of the yeast Williopsis californica JCM 3600 was developed as the key reaction. The reduction proceeded by a si-facial attack of hydride in a highly enantioselective manner. Co-factor generation was enhanced by applying glycerol as the ...