Tetrahedron letters

Highly enantioselective reduction of ketones by chiral diol-modified lithium aluminum hydride reagents

Y Ren, X Tian, K Sun, J Xu, X Xu, S Lu

文献索引：Ren, Yunlai; Tian, Xinzhe; Sun, Kunpeng; Xu, Jian; Xu, Xianlun; Lu, Shijie Tetrahedron Letters, 2006 , vol. 47, # 4 p. 463 - 465

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被引用次数: 11

摘要

Some readily available chiral diols from indene and d-mannitol were investigated as chiral modifiers in lithium aluminum hydride reduction of ketones, and it was discovered that further modification of these reducing reagents by a simple a-amino alcohol resulted in a remarkable increase in optical yield. Among the investigated chiral modifiers, chiral diol gave the highest enantioselectivities.