Synthesis of novel 3, 7-dihydro-purine-2, 6-dione derivatives

G Liu, PSMM Reddy, JR Barber, SC Ng…

文献索引：Liu, Gang; Reddy, P.S. Murali; Barber, Jack R.; Ng, Shi Chung; Zhou, Yuefen Synthetic Communications, 2010 , vol. 40, # 10 p. 1418 - 1436

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被引用次数: 2

摘要

3,7-Dihydro-purine-2,6-dione derivatives (also known as substituted xanthines) constitute an important class of pharmacologically active compounds with well-known activities as phosphodiesterase inhibitors, cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activators, and adenosine receptor antagonists. [ 1 1. (a) Dorfman , LJ ; Jarvik , ME Comparative stimulant and diuretic actions of caffeine and theobromine in man . Clin. Pharmacol. Ther. ...