High-yield production of optically active 1, 2-diols from the corresponding racemates by microbial stereoinversion

…, S Tsuda, S Maemoto, H Kutsuki, T Ohashi

文献索引：Hasegawa, Junzo; Ogura, Masahiro; Tsuda, Satoru; Maemoto, Shun-ichi; Kutsuki, Hidetoshi; Ohashi, Takehisa Agricultural and Biological Chemistry, 1990 , vol. 54, # 7 p. 1819 - 1827

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被引用次数: 110

摘要

A novel method for producing optically active 1, 2-diols by microbial Stereoinversion was developed. It was found that some microorganisms could convert only (R)-1, 2-pentanediol in the racemate to the (S)-enantiomer. Candida parapsilosis produced 27.9 g/l of (S)-1, 2- pentanediol from 30 g/l of the racemate in 24 hr of reaction (molar yield 93%, enantiomeric excess 100%). This Stereoinversion proceeded via oxidation of (R)-1, 2-pentanediol to 1- ...