Synlett

A novel, one-pot, three-component synthesis of 1, 2, 4-oxadiazoles under microwave irradiation and solvent-free conditions

…, M Mahdavi, N Mahmoodi, H Pirelahi, HR Bijanzadeh

文献索引：Adib, Mehdi; Mahdavi, Mohammad; Mahmoodi, Niusha; Pirelahi, Hooshang; Bijanzadeh, Hamid Reza Synlett, 2006 , # 11 p. 1765 - 1767

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被引用次数: 4

摘要

The most common methods recently reported for the synthesis of 1,2,4-oxadiazoles are cyclization of O-acylamidoximes obtained from acylation of amidoximes by carboxylic acids or acid chlorides. However, these methods have several drawbacks. Acid chlorides are very toxic and reactive chemicals and thus are hard to store and handle. Carboxylic acids need a coupling regent to react with amidoximes. [7] On the other hand, the reaction times are relatively ...