Synthese von Catechol??O??methyl??transferase??hemmenden Verbindungen. In den Catecholaminmetabolismus eingreifende Substanzen. 1. Mitteilung

A Carlsson, M Lindqvist, S Fila??Hromadko…

文献索引：Carlsson,A. et al. Helvetica Chimica Acta, 1962 , vol. 45, p. 270 - 276

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被引用次数: 27

摘要

Abstract The synthesis of a series of compounds with the general structure shown in formula I is described. These compounds, especially 3, 4-dihydroxyphenylacetamide (XVI), are potent and nontoxic inhibitors in vivo of catechol-O-methyl transferase. They compare favourably with pyrogallol and other known inhibitors of this enzyme.