Tetrahedron

Two new improved approaches to the synthesis of coumarin-based prodrugs

A Zheng, W Wang, H Zhang, B Wang

文献索引：Zheng, Ailian; Wang, Wei; Zhang, Huijuan; Wang, Binghe Tetrahedron, 1999 , vol. 55, # 14 p. 4237 - 4254

全文：HTML全文

被引用次数: 30

摘要

Our laboratory has recently reported the development of a coumarin-based, esterase- sensitive prodrug system for the preparation of prodrugs of amines, peptides, and peptidomimetics. Biological evaluations including animal studies have demonstrated the clinical potential of this prodrug system. However, the original synthetic method used required a long sequence of reactions with a relatively low overall yield. In this report, we ...