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Chemistry–A European Journal

A New Tool in Peptide Engineering: A Photoswitchable Stilbene??type β??Hairpin Mimetic

M Erdélyi, A Karlén, A Gogoll

文献索引:Erdelyi, Mate; Karlen, Anders; Gogoll, Adolf Chemistry - A European Journal, 2006 , vol. 12, # 2 p. 403 - 412

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被引用次数: 38

摘要

Abstract Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogenous peptides with new physicochemical and pharmacological properties. The development, synthesis, photochemical investigation, and conformational analysis of a stilbene-type β-hairpin mimetic capable of light-triggered conformational changes have been achieved. In addition to standard spectroscopic ...