Stilbene-based anticancer agents: resveratrol analogues active toward HL60 leukemic cells with a non-specific phase mechanism

…, A Di Cristina, S Grimaudo, N Gebbia, L Crosta…

文献索引：Simoni, Daniele; Roberti, Marinella; Invidiata, Francesco Paolo; Aiello, Enrico; Aiello, Stefania; Marchetti, Paolo; Baruchello, Riccardo; Eleopra, Marco; Di Cristina, Antonietta; Grimaudo, Stefania; Gebbia, Nicola; Crosta, Lucia; Dieli, Francesco; Tolomeo, Manlio Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 12 p. 3245 - 3248

全文：HTML全文

被引用次数: 70

摘要

Several stilbenes, related to known resveratrol, have been synthesized and tested for their anticancer effect on HL60 leukemia cell line, taking particular care of the cell cycle analysis. The most potent compound was the known (Z)-3, 4′, 5-trimethoxystilbene (6b) which was active as apoptotic agent at 0.24 μM. Differently from other stilbenes (including resveratrol) that induced a prevalent recruitment of cells in S phase of cell cycle, we found a peculiar ...