Peptide sweeteners. 3. Effect of modifying the peptide bond on the sweet taste of L-aspartyl-L-phenylalanine methyl ester and its analogs

…, M Chorev, FS Vernacchia, M Goodman

文献索引：MacDonald, Scott A.; Willson, C. Grant; Chorev, Michael; Vernacchia, Fred S.; Goodman, Murray Journal of Medicinal Chemistry, 1980 , vol. 23, # 4 p. 413 - 420

全文：HTML全文

被引用次数: 22

摘要

Results To study the effect of hydrogen bonding in Asp-Phe-OMe, we have synthesized the ester and N-methyl analogues. The depsipeptide L-aspartyl-(S)-phenyllactic acid methyl ester (2) was prepared by coupling N-(benzyloxy-b, n: O (a) Address: IBM Research, San Jose, Calif. 95193:(b) Address: Department of Pharmaceutical Chemistry, School of Pharmacy, The Hebrew University, Jerusalem, Israel;(c) Address: University of California, ...