Disodium (R, R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl] amino] propyl]-1, 3-benzodioxole-2, 2-dicarboxylate (CL 316,243). A potent. beta.-adrenergic agonist …

…, BD Johnson, A Wissner, MG Burns…

文献索引：Bloom, Jonathan D.; Dutia, Minu D.; Johnson, Bernard D.; Wissner, Allan; Burns, Michael G.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 16 p. 3081 - 3084

全文：HTML全文

被引用次数: 261

摘要

Such selectivity for f13-adrenoceptors could make compounds of this type potentially useful as antiobesity agents? In addition, these compounds have been reported to show antihyperglycemic effects in animal models of non-insulin-dependent diabetes A major drawback in treatment of chronic diseases with p3 agonists is the potential for stimulation of other, &receptors and subsequent side effects. The most likely of these include muscle ...