Efficient synthesis of 4-, 5-, and 6-methyl-2, 2'-bipyridine by a Negishi cross-coupling strategy followed by high-yield conversion to bromo-and chloromethyl-2, 2'- …

SA Savage, AP Smith, CL Fraser

文献索引：Savage, Scott A.; Smith, Adam P.; Fraser, Cassandra L. Journal of Organic Chemistry, 1998 , vol. 63, # 26 p. 10048 - 10051

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被引用次数: 113

摘要

Bipyridine ligands and their many complexes find wide application in chemistry. 1 These nitrogen heterocycles are common in studies of electron transfer in proteins and small molecules, 2 in supramolecular assembly, 3 and in sensing and recognition. 4 They also play a central role as ligands for copper catalysts in new living radical polymerization methodologies. 5 Despite their prevalence, many desirable bipyridine (bpy) derivatives ...