Efficient preparation of organic substrate-RNA conjugates via in vitro transcription

R Fiammengo, K Musílek…

文献索引：Fiammengo, Roberto; Musilek, Kamil; Jaeschke, Andres Journal of the American Chemical Society, 2005 , vol. 127, # 25 p. 9271 - 9276

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被引用次数: 50

摘要

A concise synthetic way has been developed for the preparation of guanosine monophosphate derivatives carrying a decaethylene glycol spacer at their 5'-oxygen to which are attached a range of organic substrates. The four different compounds, prepared via a convergent synthetic strategy, carry a tethered benzylallyl ether residue (1a), an anthracene (1b), a benzyl carbamate residue (1c), or a primary amino group (1d), ...