Synthesis of substituted indole derivatives as a new class of antimalarial agents

…, K Srivastava, SK Puri, PMS Chauhan

文献索引：Agarwal, Anu; Srivastava, Kumkum; Puri; Chauhan, Prem M.S. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 12 p. 3133 - 3136

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被引用次数: 88

摘要

A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1μg/mL. These compounds are in vitro several folds more active than pyrimethamine.