Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: effect of halogen substitution in the phenyl ring
G Roman, JG Riley, JZ Vlahakis, RT Kinobe…
文献索引：Roman, Gheorghe; Riley, John G.; Vlahakis, Jason Z.; Kinobe, Robert T.; Brien, James F.; Nakatsu, Kanji; Szarek, Walter A. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 9 p. 3225 - 3234
A series of 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes comprising imidazole– ketones, imidazole–dioxolanes, and imidazole–alcohols substituted with halogens in the phenyl ring were synthesized and evaluated as novel inhibitors of heme oxygenase which are structurally distinct from metalloporphyrins. The entire library of compounds was found to be highly active, with the bromine-and iodine-substituted derivatives being the most potent ...
